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Catalogue of Amino Acid
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A Worldwide Yearly Survey of New Data in Nandrolone Decanoate


 
Nandrolone decanoate has been reported to induce psychiatric side effects, such as aggression and depression. Adolescence represents an extremely sensitive neurodevelopmental period to influence by detrimental effects of drug abuse. A group of investigators provide some evidence regarding the effects of nandrolone decanoate on the emotional profile of animals exposed during adolescence.

Adolescent rats received daily injections of nandrolone decanoate for 14 days. Behavioral tests such as forced swim, sucrose preference, open field and elevated plus maze tests were performed at early adulthood on separate groups of animals. In vivo electrophysiological recordings were carried out to monitor changes in electrical activity of serotonergic neurons of the dorsal raphe nucleus (DRN) and noradrenergic neurons of the locus coeruleus (LC). What the authors observed was that after early exposure to nandrolone, rats displayed depression-related behavior, characterized by increased immobility in the forced swim test and reduced sucrose intake in the sucrose preference test. In addition, adult rats presented anxiety-like behavior characterized by decreased time and number of entries in the central zone of the open field and decreased time spent in the open arms of the elevated plus maze, suggesting that nandrolone decreased the firing rate of spontaneously active serotonergic neurons in the DRN while increasing the firing rate of noradrenergic neurons in the LC. Nandrolone decanoate is not recommended in adolescents, and public health measures should be taken to prevent the abuse of this compound in the developing population

Nandrolone decanoate (ND), a non-17α-alkylated modified androgen analogue of testosterone, appears to be effective in increasing LBM and muscle strength in dialysis patients. In an RCT, Johansen and colleagues assessed body composition, muscle strength, and physical functioning while administering 100 mg of ND intramuscularly weekly for 6 months in 79 MHD patients.182 Compared to baseline, ND induced a 4.5 kg LBM gain and a fat loss of 2.4 kg along with significant improvements in quadriceps muscle cross-sectional area measured by MRI and physical functioning. A dose-finding study in 54 patients on HD or PD explored the efficacy and safety of low, medium, or high doses of ND (50, 100, or 200 mg/week for 24 weeks, respectively, in males and half the dose in females).183 The results indicated that ND increased appendicular LBM in a dose-responsive manner. It was also noted that in the majority of patients ND did not increase fluid retention in excess of that associated with protein accretion and suggested dosing of ND up to 200 mg/week in males and 50 mg/week in females could be further investigated to improve body composition. On the other hand, there were notable side effects such that highest dose of ND (100 mg/week) was intolerable in females because of virilizing effects. Other potential side effects included voice change and hirsutism in women, abnormalities in prostatic markers in men, liver tests and lipid metabolism in both genders, all of which indicate that patients in future studies should be regularly followed.

Nandrolone decanoate

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